Introduction to AVIPure® - COV2S: A High-Performance Affinity Resin for Recombinant COVID-19 Vaccines
AVIPure® - COV2S resin can be used as a simple, one-step purification for the majority of recombinant COVID-19 vaccines. The affinity ligand on the AVIPure® - COV2S resin is highly selective to the receptor binding domain (RBD) within the SARS-CoV-2 virus spike protein and the RBD is the central component within all recombinant COVID-19 vaccine developers’ strategies to elicit protective immune responses. In this webinar we demonstrate the use of AVIPure® - COV2S to selectively purify four different recombinant protein COVID-19 vaccine constructs, including large trimeric spike proteins, the smaller S1 protein, and other biologics containing the receptor binding domain.
Kelley Kearns, PhD
Director of Process Development at Avitide, Inc.
- High binding capacity of SARS-CoV-2 virus spike protein including trimeric spike protein and the S1 subunit protein at typical cell culture conditions
- Cleanable with 0.5 M NaOH for efficient repetitive Clean-In-Place (CIP) and/or sanitization applications
- Excellent reduction in residual host cell protein (HCP) and host cell DNA (HCDNA)
- Compatible with standard bioprocess columns and relevant process flowrates